Neutralizing antibodies for HIV-1 prevention
نویسندگان
چکیده
منابع مشابه
Broadly Neutralizing Antibodies for HIV-1 Prevention or Immunotherapy.
n engl j med 375;21 nejm.org November 24, 2016 paid. In other words, Congress is always free to refuse to honor its debts — and it has refused to honor these particular debts. The Republicans acknowledge that an existing, permanent appropriation known as the Judgment Fund normally allows the executive branch to settle lawsuits against the United States. By its terms, however, the Judgment Fund ...
متن کاملBroadly neutralizing antibodies to prevent HIV-1.
A dvances in technology—especially single-cell antibody cloning techniques—have led to the isolation and characterization of antibodies from people with HIV infection that can neutralize many variants (1). These are referred to as broadly neutralizing antibodies (bnAbs). Such antibodies can be detected in about 25% of persons with untreated HIV-1 infection (2), reflecting a host immune response...
متن کاملOptimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection
The identification of a new generation of potent broadly neutralizing HIV-1 antibodies (bnAbs) has generated substantial interest in their potential use for the prevention and/or treatment of HIV-1 infection. While combinations of bnAbs targeting distinct epitopes on the viral envelope (Env) will likely be required to overcome the extraordinary diversity of HIV-1, a key outstanding question is ...
متن کاملTowards HIV - 1 remission : potential roles for broadly neutralizing antibodies
Introduction Combination antiretroviral therapy (ART) suppresses viremia and extends the life span of infected individuals, but the daily burden of ART and its associated toxicities make an HIV cure highly desirable. Current therapies are not curative because they do not eliminate a pool of long-lived cells harboring immunologically silent but replication-competent proviruses — termed the laten...
متن کاملTowards HIV-1 remission: potential roles for broadly neutralizing antibodies.
Current antiretroviral drug therapies do not cure HIV-1 because they do not eliminate a pool of long-lived cells harboring immunologically silent but replication-competent proviruses - termed the latent reservoir. Eliminating this reservoir and stimulating the immune response to control infection in the absence of therapy remain important but unsolved goals of HIV-1 cure research. Recently disc...
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ژورنال
عنوان ژورنال: Current Opinion in HIV and AIDS
سال: 2019
ISSN: 1746-630X
DOI: 10.1097/coh.0000000000000556